People like full-size pickup trucks, because there are many types of full-size pickup trucks (including half-ton, three-quarter-ton, and one-ton models)  and they are more versatile than any vehicle type. They can carry people inside and load outside. The downside is: They are big and aren't fuel effcient.

Regarding 4WD: Even if you won't need to take your truck in places that require 4WD, having 4WD increases the resale value of the pickup truck.

The best full-size pickup truck: Ram 1500 Big Horn Crew Cab 4WD Hemi (unique suspension, “on-demand” 4WD, the best of pickup truck + usefulnes of a crossover)

The second best full-size pickup truck: Ford F-150 XLT SuperCrew 4WD (best fuel economy, if only they didn't have the aluminum body, which is expensive and takes time to fix)

The best full-size pickup truck for carrying big loads: Chevrolet Silverado LT Crew Cab 4WD (only a bit heavy)

The best luxury full-size pickup truck: Toyota Tundra Limited CrewMax 4WD (lags on fuel economy)